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Melinamide is an amide derivative of an unsaturated long-chain fatty acid that inhibits cholesterol absorption (reported IC50 20.9 μM). Supplied as an oil or DMSO solution for research use, it is used in biochemical studies of cholesterol uptake and acyltransferase-related pathways.
Molecular formula C26H41NO
Molecular weight 383.61 g·mol⁻¹
Reported activity: IC50 20.9 μM for cholesterol absorption inhibition
Purity 99.9%
Available as oil and 10 mM DMSO solutions in multiple package sizes
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Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg and bulk. Please contact Fisher for quotes. Dimethyl succinate is found in nuts. Dimethyl succinate is present in roasted filberts. Dimethyl succinate is a flavouring ingredient. purity: 98%
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Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Omaveloxolone (RTA-408) (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-(kappa)B signaling. Phase 2. purity: 98%
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Tanshinone I is a natural diterpenoid research standard used as a phospholipase inhibitor and analytical reference for biochemical and preclinical studies. It inhibits human type IIA secreted phospholipase A2 (sPLA2) (IC50 = 11 μM) and rabbit cytosolic phospholipase A2 (cPLA2) (IC50 = 82 μM), and is supplied as a high-purity solid for laboratory use.
Natural diterpenoid research standard for biochemical assays.
Inhibits sPLA2 (human type IIA) and cPLA2 (rabbit) with reported IC50 values.
High purity suitable for analytical and research applications.
Supplied as a solid for flexible formulation and storage.
Commonly used in studies of inflammation and cardiovascular pathways.
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C12 NBD ceramide (d18:1/12:0) is a long-chain fluorescent ceramide analog that can be used for the measurement of alkaline and neutral ceramidase activity.{14063} It is hydrolyzed efficiently by alkaline ceramidase from P. aeruginosa and by neutral ceramidase from mouse liver. In addition, alkaline and neutral ceramidases from a variety of mammalian cell lines also hydrolyze C12 NBD ceramide (d18:1/12:0). Acid ceramidase does not appear to utilize C12 NBD ceramide (d18:1/12:0) as a substrate. The possibility exists forC12 NBD ceramide (d18:1/12:0) to also be applied to the measurement of ceramide kinase and/or sphingomyelin synthase activity.
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DL-alpha-tocopherol methoxypolyethylene glycol succinate is a polyethylene glycol succinate derivative of DL-alpha-tocopherol used as a solubilizer and surfactant in biological and pharmaceutical formulations. It is supplied as a solution and characterized for solubility, storage, and purity.
provides amphiphilic solubilization for hydrophobic compounds
forms clear aqueous solutions: water ≥ 50 mg/mL
soluble in PBS at 25 mg/mL with ultrasonic treatment and warming
high purity by HPLC (98.0%)
polymeric chemical formula (C2H4O)nC34H56O5; reported molecular weight approximately 605 g/mol
store as solution at -20 °C for up to 2 years
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A saturated fatty acid methyl ester; concentration in cells is modulated by methanol; inhibits phagocytosis and decreases cell viability in isolated Kupffer cells; decreases secretion of IL-10, TNF-α, NO, and PGE2 in LPS-treated cells
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A medium-chain fatty acid; has been found at high levels in coconut oil; induces the activation of NF-κB and the expression of COX-2, iNOS, and IL-1α in RAW 264.7 cells at 25 µM
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meso-2,6-diaminopimelic acid is an amino-dicarboxylic acid used in biochemical and microbiology research. It acts as the penultimate biosynthetic precursor to L-lysine and is an important component of bacterial peptidoglycan. Supplied as a solid reagent with storage and handling documentation, it is useful for studies of cell wall synthesis and lysine metabolism.
Serves as the penultimate biosynthetic precursor to L-lysine.
Useful for studies of bacterial cell wall synthesis and peptidoglycan.
Supplied as a solid; white to off-white appearance.
Available in small research quantities suitable for analytical and biochemical assays.
Documentation available, including data sheet, certificate of analysis, and safety data sheet.
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